Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells?
Stem Cells
; 28(1): 93-9, 2010 Jan.
Article
en En
| MEDLINE
| ID: mdl-19904738
ABSTRACT
Spinal cord injury (SCI) causes myelopathy, damage to white matter, and myelinated fiber tracts that carry sensation and motor signals to and from the brain. The gray matter damage causes segmental losses of interneurons and motoneurons and restricts therapeutic options. Recent advances in stem cell biology, neural injury, and repair, and the progress toward development of neuroprotective and regenerative interventions are the basis for increased optimism. This review summarizes the pathophysiological mechanisms following SCI and compares human embryonic, adult neural, and the induced pluripotent stem cell-based therapeutic strategies for SCI.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Traumatismos de la Médula Espinal
/
Trasplante de Células Madre
/
Medicina Regenerativa
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Células Madre Adultas
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Células Madre Embrionarias
/
Células Madre Pluripotentes Inducidas
/
Regeneración Nerviosa
/
Neuronas
Límite:
Adult
/
Animals
/
Humans
Idioma:
En
Revista:
Stem Cells
Año:
2010
Tipo del documento:
Article
País de afiliación:
España