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Evidence from reversal of handedness in C. elegans embryos for early cell interactions determining cell fates.
Wood, W B.
Afiliación
  • Wood WB; MRC Laboratory of Molecular Biology, Cambridge, UK.
Nature ; 349(6309): 536-8, 1991 Feb 07.
Article en En | MEDLINE | ID: mdl-1992354
ABSTRACT
Many animals with overall bilateral symmetry also exhibit some left-right asymmetries with generally invariant handedness. Therefore, the left-right embryonic axis must have a consistent polarity, whose origins and subsequent effects on development are not understood. Caenorhabditis elegans exhibits such left-right asymmetries at all developmental stages. The embryonic cell lineage is asymmetric as well although the animal is generally bilaterally symmetric, many of its contralaterally analogous cells arise from different lineages on the two sides of the embryo. I accomplished reversal of embryonic handedness by micromanipulation at the 6-cell stage, which resulted in mirror-image but otherwise normal development into healthy, fertile animals with all the usual left-right asymmetries reversed. This result demonstrates that in the 6-cell embryo the pair of anterior (AB) blastomeres on the right is equivalent to the pair on the left, and that the extensive differences in fates between lineally homologous derivatives of these cells on the two sides of the animal must be dictated by cell interactions, most of which are likely to occur early in embryogenesis.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caenorhabditis Límite: Animals Idioma: En Revista: Nature Año: 1991 Tipo del documento: Article País de afiliación: Reino Unido
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Caenorhabditis Límite: Animals Idioma: En Revista: Nature Año: 1991 Tipo del documento: Article País de afiliación: Reino Unido