Your browser doesn't support javascript.
loading
Cancer progenitors and epigenetic contexts: an Xisting connection.
Agrelo, Ruben; Wutz, Anton.
Afiliación
  • Agrelo R; Research Institute of Molecular Pathology, Vienna, Austria. agrelo@imp.ac.at
Epigenetics ; 4(8): 568-70, 2009 Nov 16.
Article en En | MEDLINE | ID: mdl-19923898
In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The non coding RNA Xist triggers X inactivation. Gene silencing by Xist is only possible in certain developmental contexts that only exist in cells of the early embryo and specific hematopoietic progenitors. Critical silencing factors may only be present in these contexts giving an explanation of why Xist is not operative outside these contexts. It has been demonstrated that Xist is functional in tumor cells, where SATB1 was identified as the first silencing factor for Xist mediated chromosome silencing.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silenciador del Gen / Epigénesis Genética / Inactivación del Cromosoma X / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Epigenetics Asunto de la revista: GENETICA Año: 2009 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Silenciador del Gen / Epigénesis Genética / Inactivación del Cromosoma X / Neoplasias Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Epigenetics Asunto de la revista: GENETICA Año: 2009 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Estados Unidos