Cancer progenitors and epigenetic contexts: an Xisting connection.
Epigenetics
; 4(8): 568-70, 2009 Nov 16.
Article
en En
| MEDLINE
| ID: mdl-19923898
In mammals, silencing of one of the two X chromosomes is necessary to achieve dosage compensation. The non coding RNA Xist triggers X inactivation. Gene silencing by Xist is only possible in certain developmental contexts that only exist in cells of the early embryo and specific hematopoietic progenitors. Critical silencing factors may only be present in these contexts giving an explanation of why Xist is not operative outside these contexts. It has been demonstrated that Xist is functional in tumor cells, where SATB1 was identified as the first silencing factor for Xist mediated chromosome silencing.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Silenciador del Gen
/
Epigénesis Genética
/
Inactivación del Cromosoma X
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Epigenetics
Asunto de la revista:
GENETICA
Año:
2009
Tipo del documento:
Article
País de afiliación:
Austria
Pais de publicación:
Estados Unidos