Low mannose-binding lectin levels and MBL2 gene polymorphisms associate with Chlamydia pneumoniae antibodies.
Innate Immun
; 17(1): 35-40, 2011 Feb.
Article
en En
| MEDLINE
| ID: mdl-19969625
ABSTRACT
OBJECTIVE:
Mannose-binding lectin (MBL) has been shown to inhibit infection of host cells by Chlamydia pneumoniae in vitro. We studied if MBL levels and MBL2 polymorphisms associate with the presence of C. pneumoniae antibodies in vivo. MATERIALS ANDMETHODS:
Single nucleotide polymorphisms (SNPs) of the MBL2 gene (promoter alleles H/L, X/Y and P/Q; and exon 1 variant alleles B, C and D and wild-type allele A) were genotyped and serum MBL concentrations and C. pneumoniae IgG, IgA and IgM antibodies were analysed in 889 Finnish military recruits.RESULTS:
An MBL level below the median concentration and the MBL2 P/P genotype were significant risk factors of IgG or IgA seroconversions or the presence of IgM antibodies during military service (adjusted odds ratio (OR) 1.5; 95% confidence interval (CI) 1.1-2.1 and OR 1.5; 95% CI 1.0-2.2, respectively). In addition, the promoter Y/Y (OR 1.6; 95% CI 1.1-2.3) and exon 1 variant allele genotypes (OR 1.4; 95% CI 1.0-2.0) were possibly associated with elevated antibodies.CONCLUSIONS:
These results suggest, for the first time, that low serum MBL levels and MBL2 polymorphisms may associate with elevated C. pneumoniae antibodies and seroconversions and thus support the previous findings in vitro.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Chlamydophila pneumoniae
/
Polimorfismo de Nucleótido Simple
/
Infecciones por Chlamydophila
/
Lectina de Unión a Manosa
/
Anticuerpos
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Innate Immun
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
BACTERIOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Finlandia