No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.
Psychiatr Genet
; 20(1): 8-13, 2010 Feb.
Article
en En
| MEDLINE
| ID: mdl-19997044
ABSTRACT
BACKGROUND:
There are conflicting reports of an association between a common functional single nucleotide polymorphism (rs6295C/G) in the serotonin-1A receptor gene (HTR1A) and psychological disorders.METHODS:
In our study we investigated associations between this polymorphism and symptoms of anxiety and depression in a population sample of 6445 Caucasians in the age groups 20-24, 40-44, and 60-64 years. We also looked for interactions between the polymorphism and environmental stressors of childhood adversity or recent stressful life events on anxiety and depression.RESULTS:
There were no significant associations between the polymorphism and anxiety, depression or associated personality traits in the three age cohorts. There were no significant gene-environment interactions between the polymorphism and either of the environmental stressors on anxiety or depression.CONCLUSION:
We found no associations or gene-environment interactions involving the polymorphism and symptoms of anxiety or depression.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ansiedad
/
Estrés Psicológico
/
Polimorfismo de Nucleótido Simple
/
Receptor de Serotonina 5-HT1A
/
Depresión
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Psychiatr Genet
Asunto de la revista:
GENETICA
/
PSIQUIATRIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Australia