Immunity-related gene single nucleotide polymorphisms associated with Rhodococcus equi infection in foals.
Int J Immunogenet
; 37(2): 67-71, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-20002811
ABSTRACT
In previous work, we found significant associations of horse polymorphic microsatellite and immunity-related (IR) gene markers with Rhodococcus equi infection of foals. Here, a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden in transtracheal aspirates was found (Fisher's F = 0.043, odds ratio 8.00, 95% confidence interval 1.127-56.795). Further positional and/or functional candidate genes investigated TLR2, IL13, IL17A, IL28R, TACE/ADAM 17 and GBP1, were not associated with infection in this study. SNPs analysed were found by sequencing and appropriate restriction fragment length polymorphism markers were developed. Their associations with R. equi infection were tested by genotyping thoroughbred foals from the original study. The association was confirmed by analysing genotypes composed with genes previously reported to be associated with R. equi infection in the same group.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Actinomycetales
/
Rhodococcus equi
/
Receptores de Interleucina-7
/
Polimorfismo de Nucleótido Simple
/
Enfermedades de los Caballos
/
Inmunidad
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Int J Immunogenet
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
GENETICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
República Checa