A two-stage search strategy for detecting multiple loci associated with rheumatoid arthritis.
BMC Proc
; 3 Suppl 7: S72, 2009 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-20018067
ABSTRACT
Gene x gene interactions play important roles in the etiology of complex multi-factorial diseases like rheumatoid arthritis (RA). In this paper, we describe our use of a two-stage search strategy consisting of information theoretic methods and logistic regression to detect gene x gene interactions associated with RA using the data in Problem 1 of Genetic Analysis Workshop 16. Our method detected interactions of several SNPs (single-SNP and SNP x SNP) that are located on chromosomal regions linked to RA and related diseases in previous studies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
BMC Proc
Año:
2009
Tipo del documento:
Article
País de afiliación:
Estados Unidos