Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease.
Parasitology
; 137(5): 755-72, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-20028608
ABSTRACT
Cerebral malaria is a life-threatening complication of malaria infection. The pathogenesis of cerebral malaria is poorly defined and progress in understanding the condition is severely hampered by the inability to study in detail, ante-mortem, the parasitological and immunological events within the brain that lead to the onset of clinical symptoms. Experimental murine models have been used to investigate the sequence of events that lead to cerebral malaria, but there is significant debate on the merits of these models and whether their study is relevant to human disease. Here we review the current understanding of the parasitological and immunological events leading to human and experimental cerebral malaria, and explain why we believe that studies with experimental models of CM are crucial to define the pathogenesis of the condition.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasmodium
/
Encéfalo
/
Malaria Cerebral
/
Modelos Animales de Enfermedad
/
Eritrocitos
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Parasitology
Año:
2010
Tipo del documento:
Article
País de afiliación:
Reino Unido