Cell size regulation during telomere-directed senescence in Saccharomyces cerevisiae.
Biosci Biotechnol Biochem
; 74(1): 195-8, 2010.
Article
en En
| MEDLINE
| ID: mdl-20057141
ABSTRACT
DNA replication without telomerase leads to telomere shortening and induces replicative senescence. We found that in a telomerase-deficient budding yeast mutant, the volume of each telomere-shortened cell increased as its growth capacity decreased, and that this process was associated with changes in vacuolar morphology. Senescence-induced cell expansion required Mec1, a DNA damage-responsive kinase, but not vacuolar SNARE Vam3.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saccharomyces cerevisiae
/
Telómero
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Asunto de la revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Japón