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Urinary excretion of IGFBP-1 and -3 correlates with disease activity and differentiates focal segmental glomerulosclerosis and minimal change disease.
Worthmann, Kirstin; Peters, Imke; Kümpers, Philipp; Saleem, Moin; Becker, Jan U; Agustian, Putri A; Achenbach, Johannes; Haller, Hermann; Schiffer, Mario.
Afiliación
  • Worthmann K; Department of Medicine/Nephrology, Hannover Medical School, Carl Neuberg Street 1, Hannover, Germany.
Growth Factors ; 28(2): 129-38, 2010 Apr.
Article en En | MEDLINE | ID: mdl-20102313
The glomerular microenvironment is influenced by circulating growth factors that are filtered from the blood stream and pass the glomerular filtration barrier. In this study, we wanted to explore the role of IGF-binding proteins (IGFBPs) in two diseases that concern podocytes. We analyzed glomerular expression and urinary excretion of IGFBP-1, -2, and -3 in patients with focal segmental glomerulosclerosis (FSGS) or minimal change disease (MCD). We found that patients with active FSGS excrete high amounts of podocalyxin positive cells as well as IGFBP-1 and -3. In human podocytes, we can induce mRNA expression of IGFBP-3 in response to TGF-beta and in human microvascular endothelial cells expression of IGFBP-1 and -3 in response to TGF-beta and Bradykinin. We conclude that the local expression of IGFBPs in podocytes and endothelial cells might contribute to the pathogenesis of glomerular disease and that IGFBP-1 and -3 are potential non-invasive markers of FSGS.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glomeruloesclerosis Focal y Segmentaria / Proteína 1 de Unión a Factor de Crecimiento Similar a la Insulina / Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina / Nefrosis Lipoidea Tipo de estudio: Diagnostic_studies Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Growth Factors Asunto de la revista: BIOLOGIA Año: 2010 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glomeruloesclerosis Focal y Segmentaria / Proteína 1 de Unión a Factor de Crecimiento Similar a la Insulina / Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina / Nefrosis Lipoidea Tipo de estudio: Diagnostic_studies Límite: Adolescent / Adult / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Growth Factors Asunto de la revista: BIOLOGIA Año: 2010 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido