Protein-phospholipid interactions in blood clotting.
Thromb Res
; 125 Suppl 1: S23-5, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-20129649
ABSTRACT
Most steps of the blood clotting cascade require the assembly of a serine protease with its specific regulatory protein on a suitable phospholipid bilayer. Unfortunately, the molecular details of how blood clotting proteins bind to membrane surfaces remain poorly understood, owing to a dearth of techniques for studying protein-membrane interactions at high resolution. Our laboratories are tackling this question using a combination of approaches, including nanoscale membrane bilayers, solid-state NMR, and large-scale molecular dynamics simulations. These studies are now providing structural insights at atomic resolution into clotting protein-membrane interactions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfolípidos
/
Coagulación Sanguínea
/
Proteínas
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Thromb Res
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos