Maternal serum ischemia-modified albumin: a biomarker to distinguish between normal pregnancy and preeclampsia?
Hypertens Pregnancy
; 29(1): 101-11, 2010 Jan.
Article
en En
| MEDLINE
| ID: mdl-20132025
ABSTRACT
OBJECTIVE:
To determine whether a biological marker of ischemia, ischemia-modified albumin (IMA), alone or normalized to albumin serum concentration, was modified during the course of pregnancy and so could be used for discrimination between normal pregnancy and preeclampsia.METHODS:
Serum IMA concentrations and IMA to serum albumin ratio (IMA/alb) were compared in 22 nonpregnant healthy women (NP), 19 healthy pregnant women (HP) and 20 pre-eclamptic women (PE). Influence of age of gestation on these markers was also investigated.RESULTS:
IMA to albumin ratio (IMA/alb) was significantly increased in HP compared with NP (IMA/alb. HP 2.60 +/- 0.38 kU/g and IMA/alb. NP 2.10 +/- 0.22 kU/g; p < 0.05). Both IMA and IMA/alb were significantly elevated during PE compared with HP (IMA HP 98.4 +/- 9.2 kU/l and IMA PE 116.9 +/- 12.3 kU/l, p < 0.001; IMA/alb HP 2.60 +/- 0.38 kU/g and IMA/alb PE 3.79 +/- 0.75 kU/g p < 0.001)). Both IMA and IMA/alb were increased in PE up to delivery. No correlation could be demonstrated between gestational age and maternal IMA both in HP (r = 0.13; p = 0.071) or PE (r = 0.05; p = 0.318).CONCLUSIONS:
IMA and IMA normalized to albumin appear to be significantly increased during pathological pregnancies. These results confirm that IMA could be used as a biological marker of preeclampsia. These data need to be confirmed by determining intra-individual IMA change during normal and pathological pregnancy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Preeclampsia
/
Albúmina Sérica
/
Isquemia
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Hypertens Pregnancy
Asunto de la revista:
ANGIOLOGIA
/
OBSTETRICIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Francia