Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans.
Proc Natl Acad Sci U S A
; 107(8): 3770-5, 2010 Feb 23.
Article
en En
| MEDLINE
| ID: mdl-20133713
ABSTRACT
GNA2132 is a Neisseria meningitidis antigen of unknown function, discovered by reverse vaccinology, which has been shown to induce bactericidal antibodies in animal models. Here we show that this antigen induces protective immunity in humans and it is recognized by sera of patients after meningococcal disease. The protein binds heparin in vitro through an Arg-rich region and this property correlates with increased survival of the unencapsulated bacterium in human serum. Furthermore, two proteases, the meningococcal NalP and human lactoferrin, cleave the protein upstream and downstream from the Arg-rich region, respectively. We conclude that GNA2132 is an important protective antigen of N. meningitidis and we propose to rename it, Neisserial Heparin Binding Antigen (NHBA).
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Sanguíneas
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Proteínas Portadoras
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Péptidos Catiónicos Antimicrobianos
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Vacunas Meningococicas
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Factores de Virulencia
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Antígenos Bacterianos
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Neisseria meningitidis
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
2010
Tipo del documento:
Article
País de afiliación:
Italia