Pharmacokinetic-pharmacodynamic assessment of faropenem in a lethal murine Bacillus anthracis inhalation postexposure prophylaxis model.
Antimicrob Agents Chemother
; 54(5): 1678-83, 2010 May.
Article
en En
| MEDLINE
| ID: mdl-20145081
ABSTRACT
There are few options for prophylaxis after exposure to Bacillus anthracis, especially in children and women of childbearing potential. Faropenem is a beta-lactam in the penem subclass that is being developed as an oral prodrug, faropenem medoxomil, for the treatment of respiratory tract infections. Faropenem was shown to have in vitro activity against B. anthracis strains that variably express the bla1 beta-lactamase (MIC range,
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacillus anthracis
/
Beta-Lactamas
/
Carbunco
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos