Molecular analysis of the CART gene in overweight and obese Italian children using family-based association methods.
Acta Paediatr
; 99(5): 722-726, 2010 May.
Article
en En
| MEDLINE
| ID: mdl-20151954
ABSTRACT
AIM:
In our study, we evaluated if CART gene A1475G and DeltaA1457 polymorphisms could be associated with obesity. PATIENTS ANDMETHODS:
We recruited 133 Italian trios from among 103 (50 males and 53 females) overweight children (mean age 10.5 years, range 6-14 years; mean BMI 26.1 +/- 3.2 kg/m(2)), and 30 (16 males and 14 females) obese children (mean age 9.0 years, range 6-11 years; mean BMI 32.3 +/- 2.0 kg/m(2)). We also selected 187 non-obese unrelated controls.RESULTS:
The allele frequencies of the A1475G single nucleotide polymorphism (SNP) were significantly higher in overweight children (0.07) than in control children (0.02) (p = 0.03) and control adults (0.02) (p = 0.02). Moreover, the allele frequencies were significantly different between obese children (0.08) and control children (0.02) (p = 0.03), and between obese children (0.08) and control adults (0.02) (p = 0.02). The DeltaA1457 SNP showed no significant association with overweight/obesity. TDT statistic revealed a preferential transmission of the 1475G allele from heterozygous parents to overweight children (p < 0.01) and to obese children (p < 0.05). No statistically significant excess transmission of the DeltaA1457 allele was found.CONCLUSION:
Our results supported the hypothesis that inherited variations of the CART gene could influence the development of obesity also in Italian children.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Familia
/
Predisposición Genética a la Enfermedad
/
Sobrepeso
/
Proteínas del Tejido Nervioso
/
Obesidad
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Acta Paediatr
Año:
2010
Tipo del documento:
Article
País de afiliación:
Italia