Delayed gadolinium-enhanced MRI of cartilage in the ankle at 3 T: feasibility and preliminary results after matrix-associated autologous chondrocyte implantation.
J Magn Reson Imaging
; 31(3): 732-9, 2010 Mar.
Article
en En
| MEDLINE
| ID: mdl-20187220
ABSTRACT
PURPOSE:
To demonstrate the feasibility of delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) in the ankle at 3 T and to obtain preliminary data on matrix associated autologous chondrocyte (MACI) repair tissue. MATERIALS ANDMETHODS:
A 3D dual flip angle sequence was used with an eight-channel multipurpose coil at 3 T to obtain T1 maps both pre- and postintravenous contrast agent (Magnevist, 0.2 mM/kg). Postcontrast T1 over time was evaluated in three volunteers; a modified dGEMRIC protocol was then used to assess 10 cases after MACI in the ankle.RESULTS:
Forty-five minutes were found sufficient for maximum T1 decrease. MACI cases had a precontrast mean T1 of 1050 +/- 148.4 msec in reference cartilage (RC) and 1080 +/- 165.6 msec in repair tissue (RT). Postcontrast T1 decreased to 590 +/- 134.0 msec in RC and 554 +/- 133.0 msec in RT. There was no significant difference between the delta relaxation rates in RT (9.44 x 10(-4) s(-1)) and RC (8.04 x 10(-4) s(-1), P = 0.487). The mean relative delta relaxation rate was 1.34 +/- 0.83.CONCLUSION:
It is feasible to assess the thin cartilage layers of the ankle with dGEMRIC at 3 T; MACI can yield RT with properties similar to articular cartilage.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
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Traumatismos del Tobillo
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Condrocitos
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Gadolinio DTPA
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Fracturas del Cartílago
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
J Magn Reson Imaging
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
Año:
2010
Tipo del documento:
Article
País de afiliación:
Austria