Abnormal fatty acid metabolism in patients in hopantenate therapy during clinical episodes.
J Chromatogr
; 562(1-2): 139-45, 1991 Jan 02.
Article
en En
| MEDLINE
| ID: mdl-2026687
ABSTRACT
Calcium 4-(2,4-dihydroxy-3,3-dimethylbutyramido)butyrate hemihydrate (hopantenate), a cerebral metabolic enhancer used in Japan since 1978, is a homologue of pantothenic acid. Using mass spectrometry, we found urinary excretion of 4-hydroxydodecanedioic acid, 4-hydroxytetradecanedioic acid and a series of 2-hydroxydicarboxylic acids (C8-C14), in addition to a series of odd- and even-numbered dicarboxylic acids (C5-C12) and 3-hydroxydicarboxylic acids (C8-C14) in patients receiving hopantenate during episodes of Reye's-like syndrome. Our findings suggest that an acute intoxication associated with hopantenate occurs owing to pantothenic acid deficiency or the inhibition of CoA-requiring reactions during stress, i.e. infection, prolonged fasting, or malnutrition.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Pantoténico
/
Ácidos Grasos
/
Ácido gamma-Aminobutírico
Límite:
Aged
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Chromatogr
Año:
1991
Tipo del documento:
Article
País de afiliación:
Japón