Basement membranes in development and disease.
Birth Defects Res C Embryo Today
; 90(1): 8-31, 2010 Mar.
Article
en En
| MEDLINE
| ID: mdl-20301220
ABSTRACT
Basement membranes (BMs) are specializations of the extracellular matrix that act as key mediators of development and disease. Their sheet like protein matrices typically serve to separate epithelial or endothelial cell layers from underlying mesenchymal tissues, providing both a biophysical support to overlying tissue as well as a hub to promote and regulate cell-cell and cell-protein interactions. In the latter context, the BM is increasingly being recognized as a mediator of growth factor interactions during development. In this review, we discuss recent findings regarding the structure of the BM and its roles in mediating the normal development of the embryo, and we examine congenital diseases affecting the BM which impact embryonic development and health in later life.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anomalías Congénitas
/
Membrana Basal
/
Desarrollo Embrionario
/
Matriz Extracelular
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Birth Defects Res C Embryo Today
Asunto de la revista:
EMBRIOLOGIA
/
TERATOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Australia