Antitumor-promoting activity of lignans: inhibition of human cytomegalovirus IE gene expression.
Anticancer Res
; 30(2): 451-4, 2010 Feb.
Article
en En
| MEDLINE
| ID: mdl-20332453
ABSTRACT
BACKGROUND:
Chemoprevention is a promising new approach to cancer prevention. Since the beginning of chemoprevention studies, short-term in vitro models used in the study of carcinogenesis have been applied in the identification of antitumor-promoting agents. MATERIALS ANDMETHODS:
The lignans threo-4,4'-dihydroxy-3-methoxylignan, (-)-dihydroguaiaretic acid, 4'-hydroxy-3,3',4-trimethoxylignan, 3,3',4,4'-tetramethoxylignan, 4,4'-diacetyl-3,3'-dimethoxylignan, talaumidin, heliobuphthalmin, (-)-dihydro-cubebin, and hinokinin were evaluated for their ability to inhibit human cytomegalovirus (HCMV) IE-antigen expression in lung cancer cells (A549).RESULTS:
Most of the evaluated compounds reduced IE-antigen expression of HCMV, the best result being obtained with 4,4'-dihydroxy-3-methoxylignan. However, a dose-dependent significant increase of IE-antigen expression was found for the derivative (-)-dihydrocubebin.CONCLUSION:
The results of this study suggest that some of these lignans might be valuable as potential cancer chemopreventive agents.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Regulación Viral de la Expresión Génica
/
Lignanos
/
Proteínas Inmediatas-Precoces
/
Neoplasias Pulmonares
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Anticancer Res
Año:
2010
Tipo del documento:
Article
País de afiliación:
Hungria