[Preliminary study on genotype of hepatitis B virus detected from Xinjiang Uygur Autonomous Region in China].

ABSTRACT

OBJECTIVE: To determine the main genotype of hepatitis B virus (HBV) in Xinjiang. METHODS: 200 HBsAg positive serum specimens were detected from more than 2000 serum of Xinjiang inhabitants, and HBV S gene was detected by using nPCR amplifying, and compared with the standard S region HBV nucleotide sequences of genotypes A-H retrieved from GenBank, then analyzed and drawn the polygenetic tree by MEGA3 software. RESULT: Gene in 127 (63.5%) serum specimens was detected from 200 samples. Among 127 serum specimens, 10 (7.8%) was genotype B, 58 (45.7%) was genotype C, and 59 (46.5%) was genotype D. CONCLUSION: Genotype B, C and D have been found in Xinjiang.