Safety and efficacy of an inactivated Carbopol-adjuvanted goose haemorrhagic polyomavirus vaccine for domestic geese.
Avian Pathol
; 39(2): 111-6, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-20390545
ABSTRACT
Haemorrhagic nephritis enteritis of the goose (HNEG) is an epizootic viral disease in domestic geese. The causal agent is a polyomavirus, namely goose haemorrhagic polyomavirus. To help control the disease, an inactivated vaccine was developed, based on viral particles produced in goose kidney cells. Viral material was quantified using real-time quantitative polymerase chain reaction, inactivated with beta-propiolactone and adjuvanted with Carbopol, an acrylic acid polymer. Carbopol proved to be more immunogenic than aluminium hydroxide and was totally safe when administered to young goslings and breeders alike. Carbopol-adjuvanted vaccine induced a high serological response. Moreover, goslings hatched from vaccinated breeders were protected against viral challenge, indicating that maternally-derived neutralizing antibodies (MDA) were efficiently transferred. MDA were still detectable 15 days post-hatch. Clinical trials will be necessary to accurately evaluate a vaccine-based HNEG control strategy under field conditions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polivinilos
/
Enfermedades de las Aves de Corral
/
Vacunas Virales
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Adyuvantes Inmunológicos
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Poliomavirus
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Infecciones por Polyomavirus
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Gansos
Límite:
Animals
Idioma:
En
Revista:
Avian Pathol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Francia