[Histone demethylase LSD1 and its biological functions].
Yi Chuan
; 32(4): 331-8, 2010 Apr.
Article
en Zh
| MEDLINE
| ID: mdl-20423886
ABSTRACT
Discovery of histone lysine specific demethylase 1 (LSD1) indicates that even histone methylation is reversible. Structural analysis shows that LSD1 is a flavin-dependent amine oxidase, which is able to catalyze the specific removal of methyl groups from mono- and dimethylated Lys4 and Lys9 of histone H3. Functional studies demonstrate that LSD1 regulates activation and inhibition of gene transcription in the nucleus, which is known as the innermost gene switch of cells. LSD1 plays important roles in embryonic development and tumorigenesis. Here, we review recent insights into the structure and chemical mechanism of LSD1, and its regulatory roles in development and cancer.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Histona Demetilasas
Límite:
Animals
/
Humans
Idioma:
Zh
Revista:
Yi Chuan
Asunto de la revista:
GENETICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
China