Morphologic features of melanophages under in vivo reflectance confocal microscopy.
Arch Dermatol
; 146(5): 492-8, 2010 May.
Article
en En
| MEDLINE
| ID: mdl-20479296
ABSTRACT
OBJECTIVES:
To determine morphologic features of melanophages under in vivo reflectance confocal microscopy (RCM) and to highlight morphologic features that are important in distinguishing melanophages from melanocytes.DESIGN:
Consecutive retrospective study.SETTING:
Referral center for pigmented lesions. PATIENTS The study group retrospectively constituted 20 consecutive patients having biopsy-proven lichen planus-like keratoses that dermoscopically and histopathologically showed many melanophages and that had been imaged under RCM before biopsy. MAIN OUTCOMEMEASURES:
The RCM characteristics of isolated dermal bright cells were scored blinded to dermoscopic features and histopathologic diagnosis.RESULTS:
Under RCM, melanophages were significantly smaller than melanocytes (mean [SD] cell diameter, 13.6 [1.6] vs 18.2 [2.9] microm, P = .006). Nuclei (intracellular low-reflectance round-oval structures) were visible in only 16% (29 of 184) of the cells in melanophages vs 57% (28 of 49) of the cells in melanocytes (P < .001). When identified, nuclei were smaller in melanophages than in melanocytes (mean [SD] diameter, 3.2 [1.2] vs 6.4 [0.7] microm, P < .001). Compared with melanocytes, melanophages were significantly more ill defined (76% [140 of 184] vs 18% [9 of 49], P < .001), less round (23% [42 of 184] vs 69% [34 of 49], P < .001), and less dendritic (1% [2 of 184] vs 12% [6 of 49]) (P = .001).CONCLUSION:
Observed differences in morphologic features should enable distinction between melanophages and melanocytes under RCM, thereby improving the accuracy of skin lesion diagnosis using this technique.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Microscopía Confocal
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Liquen Plano
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Macrófagos
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Melaninas
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Melanocitos
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Arch Dermatol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Australia