Immunity to Leishmania and the rational search for vaccines against canine leishmaniasis.
Trends Parasitol
; 26(7): 341-9, 2010 Jul.
Article
en En
| MEDLINE
| ID: mdl-20488751
ABSTRACT
The control of infection by Leishmania infantum (syn. Leishmania chagasi) in dogs is essential to stop the current spread of zoonotic visceral leishmaniasis. The past few years have seen significant advances in achieving efficient immunization of dogs and, more than ever before, an effective vaccine against canine leishmaniasis can now be considered a feasible goal. This article summarizes experimental data gathered from recent dog trials aimed at identifying immunological mechanisms implicated in protection against canine infection to discuss their potential to serve as quantitative surrogate markers of immunization and, more importantly, its usefulness to evaluate whether the immunity induced by the vaccine candidate is strong enough to protect against canine leishmaniasis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas Antiprotozoos
/
Enfermedades de los Perros
/
Leishmania
/
Leishmaniasis Visceral
Límite:
Animals
Idioma:
En
Revista:
Trends Parasitol
Asunto de la revista:
PARASITOLOGIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Brasil