PET and SPECT imaging of the NMDA receptor system: an overview of radiotracer development.
Mini Rev Med Chem
; 10(9): 870-86, 2010 Aug.
Article
en En
| MEDLINE
| ID: mdl-20504276
ABSTRACT
Imaging the N-methyl-D-aspartate receptors (NMDARs) in the living human brain by positron emission tomography (PET) or single photon emission computed tomography (SPECT) would provide useful information on the role of these receptors in ischemia and in various neurological disorders such as degenerative diseases, epilepsy or schizophrenia. To assess NMDAR radiotracer development and to propose perspectives, we overviewed the PET and SPECT candidate radioligands developed until now. Labelled molecules of interest were classified in three groups according to their binding site intrachannel pore site blockers, glycine site inhibitors and NR2B selective subunit antagonists.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tomografía Computarizada de Emisión de Fotón Único
/
Receptores de N-Metil-D-Aspartato
/
Radiofármacos
/
Tomografía de Emisión de Positrones
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Mini Rev Med Chem
Asunto de la revista:
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Francia