Cytoprotective effects of calcium channel blockers. Mechanisms and potential applications in hepatocellular injury.
J Hepatol
; 12(2): 251-5, 1991 Mar.
Article
en En
| MEDLINE
| ID: mdl-2051005
ABSTRACT
Deregulation of calcium homeostasis is strongly implicated in the development of cellular injury, including in hepatocytes, and is thought to be the limiting step in transition to an irreversible stage. Calcium channel blockers appear to exert their cytoprotective effects through several mechanisms. These may involve blockade of L-(long-lasting)-type calcium channels, reduction of oxidative stress, antagonism at inflammatory mediator receptor sites and interaction at other intracellular sites. Studies relating to the liver are few but suggest that calcium channel blockers may have a role to play in limiting hepatocellular damage, especially those arising from exposure to a variety of toxic agents.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bloqueadores de los Canales de Calcio
/
Hígado
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Hepatol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
1991
Tipo del documento:
Article
País de afiliación:
Reino Unido