Your browser doesn't support javascript.
loading
The role of immunosuppression in malignancies among 351 pediatric renal transplant patients.
Berardinelli, L; Raiteri, M; Ghio, L; Messa, P G; Montagnino, G.
Afiliación
  • Berardinelli L; General Surgery and Kidney Transplantation Unit, Policlinico University Hospital IRCCS, Milan, Italy. luisa.berardinelli@unimi.it
Transplant Proc ; 42(4): 1166-8, 2010 May.
Article en En | MEDLINE | ID: mdl-20534251
The incidence of de novo malignancies over a 38 year experience in 351 children ranging in age from 2 to 18 years was investigated among subjects prescribed various immunosuppressive protocols. There were 14 children (3.98%) who showed de novo malignancies, namely, 4.86 cancers for every 1000 graft-function years (GFYs). Among patients who had grafts functioning for >10 years, 7.4% suffered from cancer. Nine patients survive without a recurrence at a mean of 12.5 +/- 6.6 years including 6 with graft function. Among group I who were treated with pre-calcineurin inhibitor (CNI) therapy 3 (3.8%) children (1 male and 2 females) developed a malignancy at a mean of 15.2 +/- 11.9 years posttransplant (range, 7-35), for 4.65 cancers every 1000 GFYs. Two of them survive with functioning grafts. Among group II, who were treated by CNIs there were 273 children including 24 retransplants. Group II showed 11 malignancies (4.0%), for 5.04 malignancies for every 1000 GFYs. The incidence of cancer was similar in the 2 groups, undergoing different immunosuppressive regimens; however, the malignancies in the CNI- group were more precocious, compared with those of the conventionally-treated cohort.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia de Inmunosupresión / Trasplante de Riñón / Neoplasias Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Transplant Proc Año: 2010 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Terapia de Inmunosupresión / Trasplante de Riñón / Neoplasias Tipo de estudio: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Transplant Proc Año: 2010 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos