Effect of aripiprazole versus haloperidol on PANSS Prosocial items in early-episode patients with schizophrenia.
Schizophr Res
; 120(1-3): 199-203, 2010 Jul.
Article
en En
| MEDLINE
| ID: mdl-20547037
ABSTRACT
BACKGROUND AND AIM:
Improving social functioning is critically important in early-episode schizophrenia, if patients are to achieve functional recovery. This post-hoc, pooled analysis of two studies compared the effect of aripiprazole versus haloperidol on social functioning in early-episode schizophrenia.METHODS:
Data were pooled from two 52 week, randomized (21), double-blind, multicenter studies involving 1294 patients with chronic schizophrenia who were in an acute psychotic episode and had a history of positive antipsychotic response during previous episodes. The early-episode group was defined as patients who areRESULTS:
Aripiprazole (n=237) demonstrated significant improvement versus haloperidol (n=123) as early as Week 18 on both the Prosocial subscale (-4.75 versus -3.78, p<0.05) and on the Modified Prosocial subscale (-3.16 versus -2.28, p<0.05). Patients receiving aripiprazole continued to show similar significant improvement versus haloperidol at all remaining timepoints through Week 52 using the Modified Prosocial subscale, but less consistent improvement with the Prosocial subscale. Significant advantage for the aripiprazole-treated patients was observed at Weeks 46 and 52 (endpoint) with both subscales.CONCLUSION:
In patients with early-episode schizophrenia, aripiprazole demonstrates greater improvement than haloperidol on PANSS items related to social functioning. The cognitive and functional implications of these findings remain to be clarified in future studies.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piperazinas
/
Esquizofrenia
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Psicología del Esquizofrénico
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Trastorno de la Conducta Social
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Antipsicóticos
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Quinolonas
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Haloperidol
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Límite:
Adolescent
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Adult
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Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Schizophr Res
Asunto de la revista:
PSIQUIATRIA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos