Caesium fluoride-induced changes in the c.d. spectra of synthetic DNA fragments.
Int J Biol Macromol
; 13(1): 9-13, 1991 Feb.
Article
en En
| MEDLINE
| ID: mdl-2059585
ABSTRACT
Ten DNA fragments containing self-complementary alternating sequences of adenine and thymine differing in length and the starting nucleotide were studied by c.d. spectroscopy. It was found that d(TATATATA) but not d(ATATATAT), d(TATATA), d(CTATATAG) or (dT-dA)20 isomerized into the unusual X-DNA double helix at molar concentrations of CsF in solution. But in contrast to poly(dA-dT), the octamer (dT-dA)4, isomerized very slowly, at relatively low CsF concentrations and the isomerization was strongly dependent on the octamer concentration. A model is proposed to account for the observed properties of the B-to-X isomerization on the oligomer level.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligonucleótidos
/
Polinucleótidos
/
ADN
/
Fluoruros
Idioma:
En
Revista:
Int J Biol Macromol
Año:
1991
Tipo del documento:
Article