Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.
J Neuroimmunol
; 227(1-2): 44-51, 2010 Oct 08.
Article
en En
| MEDLINE
| ID: mdl-20615555
ABSTRACT
Mdx mice develop an inflammatory myopathy characterized at different ages by myonecrosis with scattered inflammatory infiltrates followed by muscular regeneration and later persistent fibrosis. This work aimed to verify the putative anti-inflammatory role of nicotinic acetylcholine receptor (nAChR) in the mdx muscular lesion. Mitigation of myonecrosis and decreased TNFα production were accompanied by increased numbers of F4/80 macrophages expressing nAChRα7. In vivo treatment with nicotine attenuated muscular inflammation characterized by reduced metalloprotease MMP-9 activity, TNFα and NFkB content and increased muscular regeneration. Our data indicate that nAChR activation influences local inflammatory responses in the muscular lesion of mdx mice.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Receptores Nicotínicos
/
Músculo Esquelético
/
Mediadores de Inflamación
/
Miositis
Límite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Año:
2010
Tipo del documento:
Article
País de afiliación:
Brasil