Discovery and optimization of pyrazoline compounds as B-Raf inhibitors.
Bioorg Med Chem Lett
; 20(16): 4800-4, 2010 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-20634068
ABSTRACT
The discovery of novel pyrazoline derivatives as B-Raf (V600E) inhibitors is described in this report. Chemical modification of the pyrazoline scaffold led to the development of SAR and identified potent and selective inhibitors of B-Raf (V600E). Determination of the pharmacokinetic properties of selected inhibitors is also reported.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirazoles
/
Proteínas Proto-Oncogénicas B-raf
/
Inhibidores de Proteínas Quinasas
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos