[Study of follicle-stimulating hormone receptor and tyrosine hydroxylase polymorphisms and pre-eclampsia in Chinese Han population].
Zhonghua Yi Xue Za Zhi
; 90(17): 1213-5, 2010 May 04.
Article
en Zh
| MEDLINE
| ID: mdl-20646572
ABSTRACT
OBJECTIVE:
To analyze a potential association of gene polymorphisms of the follicle-stimulating hormone receptor (FSHR) gene rs1394205 polymorphism and tyrosine hydroxylase (TH) rs2070762 polymorphism with pre-eclampsia.METHODS:
The gene polymorphism of FSHR rs1394205 and TH rs2070762 were analyzed by real-time Quantitative polymerase chain reaction (TaqMan probe) in 105 patients with pre-eclampsia and 103 healthy pregnant subjects in Chinese Han population. Genotype and allele were assessed by direct counting methods. And the associations between 2 SNPs and pre-eclampsia were analyzed by chi-square test.RESULTS:
The frequencies of the TH gene rs2070762 polymorphism CC, C/T and TT genotypes were 14.6%, 42.7% and 42.7% in pre-eclampsia group and 18.1%, 56.2% and 25.7% in normal control group respectively. The allelic frequency of rs2070762 polymorphism in TH in pre-eclampsia patients was significantly lower (P < 0.05) than that in normal pregnancies. There was a significant difference between two groups (P < 0.05). But there was no significant difference between mild and severe pre-eclampsia groups (P > 0.05). In contrast, no significant association was detected in the comparison of genotypes and allele of FSHR gene rs1394205 between pre-eclampsia patients and normal pregnancies.CONCLUSION:
The TH rs2070762 polymorphism was associated with the pathogenesis of pre-eclampsia. It suggests that the polymorphism in TH may be involved in the onset and development of pre-eclampsia.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Preeclampsia
/
Tirosina 3-Monooxigenasa
/
Receptores de HFE
/
Polimorfismo de Nucleótido Simple
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
Zh
Revista:
Zhonghua Yi Xue Za Zhi
Año:
2010
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
CHINA
/
CN
/
REPUBLIC OF CHINA