ADAMTS proteases: key roles in atherosclerosis?
J Mol Med (Berl)
; 88(12): 1203-11, 2010 Dec.
Article
en En
| MEDLINE
| ID: mdl-20652528
ABSTRACT
The ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteases are secreted enzymes that regulate extracellular matrix turnover by degrading specific matrix components. Roles for the proteases in inflammation and atherosclerosis have been suggested by a number of recent studies, and the role of ADAMTS-4 and -5 in the breakdown of aggrecan and subsequent degradation of cartilage during osteoarthritis has also been established. The ability of the ADAMTS proteases to degrade versican, the primary proteoglycan in the vasculature, is thought to be central to any hypothesized role for the proteases in atherosclerosis. In this review, we introduce the structure and function of the ADAMTS family of proteases and review the literature that links them with inflammation and atherosclerosis.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aterosclerosis
/
Proteínas ADAM
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Mol Med (Berl)
Asunto de la revista:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Año:
2010
Tipo del documento:
Article
Pais de publicación:
ALEMANHA
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ALEMANIA
/
DE
/
DEUSTCHLAND
/
GERMANY