N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death.
Cancer Lett
; 298(2): 186-94, 2010 Dec 08.
Article
en En
| MEDLINE
| ID: mdl-20667650
ABSTRACT
A variety of metal-binding compounds have been found to exert anti-cancer activity. We postulated that N-acetylcysteine (NAC), which is a membrane-permeable metal-binding compound, might have anti-cancer activity in the presence of metals. We found that NAC/Cu(II) significantly alters growth and induces apoptosis in human cancer lines, yet NAC/Zn(II) and NAC/Fe(III) do not. We further confirmed that this cytotoxicity of NAC/Cu(II) is attributed to reactive oxygen species (ROS). These findings indicate that the combination of Cu(II) and thiols generates cytotoxic ROS that induce apoptosis in cancer cells. They also indicate a fourth class of anti-neoplastic metal-binding compounds, the "ROS generators".
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Acetilcisteína
/
Apoptosis
/
Cobre
/
Peróxido de Hidrógeno
Límite:
Humans
Idioma:
En
Revista:
Cancer Lett
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos