The interaction between cerebrovascular disease and neuroticism in late-life depression: a cross-sectional study.
Int J Geriatr Psychiatry
; 26(7): 702-10, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-20677172
ABSTRACT
OBJECTIVE:
Vascular disease and neuroticism are both risk factors for late-life depression. In this study we examined the interaction between vascular disease and neuroticism as determinants of clinically relevant depressive symptoms (CRDS) in late-life.METHODS:
Multivariate logistic regression in a survey of 1396 population-dwelling people aged ≥70 years. CRDS were defined as scoring ≥16 on the CES-D. Vascular disease was categorised into four levels none, ≥2 vascular risk factors, cardiac disease or stroke.RESULTS:
Neuroticism was strongly associated with CRDS in women (OR 1.6, 95% CI 1.4-1.8). In men vascular disease interacted negatively but significantly with neuroticism (cardiac disease by neuroticism OR 0.8, 95% CI 0.6-0.9; stroke by neuroticism OR 0.8, 95% CI 0.6-0.96) when predicting CRDS.CONCLUSIONS:
In men vascular disease attenuates the predictive value of neuroticism in CRDS, which might be mediated by apathy caused by cerebrovascular disease.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos Cerebrovasculares
/
Trastorno Depresivo
/
Trastornos Neuróticos
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Int J Geriatr Psychiatry
Asunto de la revista:
GERIATRIA
/
PSIQUIATRIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Países Bajos