A novel inhibitor of IL-1 generation, E5090: in vitro inhibitory effects on the generation of IL-1 by human monocytes.
Agents Actions Suppl
; 32: 225-9, 1991.
Article
en En
| MEDLINE
| ID: mdl-2069091
ABSTRACT
E5090 is an orally active inhibitor of IL-1 generation, being converted in vivo into the pharmacologically active deacetylated form (DA-E5090). In vitro effects of DA-E5090 on the generation of IL-1 by human monocytes stimulated with LPS were examined. DA-E5090 inhibited both IL-1 alpha and IL-1 beta generation by human monocytes stimulated with 1 microgram/ml of LPS in a dose dependent-manner (1-10 microM), as determined by LAF assay and ELISA. Northern blotting analysis indicated that DA-E5090 inhibits transcription of IL-1 alpha and IL-1 beta m-RNAs.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Acrilatos
/
Monocitos
/
Antiinflamatorios no Esteroideos
/
Interleucina-1
/
Naftoles
Límite:
Humans
Idioma:
En
Revista:
Agents Actions Suppl
Año:
1991
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND