Tumor localization in nude mice bearing human breast carcinoma xenografts using 111In-DTPA conjugates of monoclonal antibodies.
Int J Rad Appl Instrum B
; 18(3): 295-304, 1991.
Article
en En
| MEDLINE
| ID: mdl-2071442
Biodistribution of monoclonal antibody T43 and its F(ab')2 111In-DTPA conjugates were determined in nu/nu mice bearing human breast tumor and rat pituitary tumor xenografts. T43 localized in the target tumor with tumor/blood ratios of 3.9 (P less than 0.01) and 4.5 (P less than 0.05) at 48 and 72 h, respectively. T43 F(ab')2 fragments localized with tumor/blood ratio of 14.2 (P less than 0.1) at 72 h. Tumors as small as 4 mm were detected without computer subtraction technique. These studies suggest that T43 and T43 F(ab')2 might be useful reagents in radioimaging.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Ácido Pentético
/
Anticuerpos Monoclonales
/
Neoplasias Experimentales
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Int J Rad Appl Instrum B
Asunto de la revista:
BIOLOGIA
/
MEDICINA NUCLEAR
Año:
1991
Tipo del documento:
Article
Pais de publicación:
Reino Unido