Functional alterations induced by the food contaminant furazolidone on the human tumoral intestinal cell line Caco-2.
Toxicol In Vitro
; 7(4): 403-6, 1993 Jul.
Article
en En
| MEDLINE
| ID: mdl-20732223
ABSTRACT
Caco-2 cells, which are derived from a human colon carcinoma and are able to differentiate in culture, have been used to study the effect of furazolidone (FZ), a chemical belonging to the nitrofuran family which is frequently used for the prevention of animal infections. Its potentially toxic residues could remain in some food products of animal origin and affect human health. Toxicity has been measured by different parameters, either in undifferentiated cells (day 7 of culture), or on differentiated cells (day 21 of culture). Our results indicate that FZ may seriously affect the proliferating portion of the intestinal mucosa, while the differentiated cells appear to be more resistant. However, the slight effect recorded on the aspecific and specific functions of the differentiated cells may suggest that the specialized portion of the intestine can also be compromised by the drug. Caco 2 cells seem a good model for a deeper investigation of the mechanism involved in the toxic action of FZ.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Toxicol In Vitro
Asunto de la revista:
TOXICOLOGIA
Año:
1993
Tipo del documento:
Article
País de afiliación:
Italia