Movement within and movement beyond: synaptotagmin-mediated vesicle fusion during chemotaxis.
Cell Adh Migr
; 5(1): 56-8, 2011.
Article
en En
| MEDLINE
| ID: mdl-20798599
ABSTRACT
Leukocyte chemotaxis plays an essential role in generating and delivering immune responses and is a critical component of inflammation. In order to identify novel genes and pathways important for regulating chemotaxis, we performed an RNAi-based screen and identified several genes involved with vesicle movement and fusion as mediators of chemotaxis. Our recently published data show that during chemotaxis vesicle trafficking proteins are required for lysosome fusion, uropod release and efficient directed cell migration.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Movimiento Celular
/
Quimiotaxis de Leucocito
/
Interferencia de ARN
/
Sinaptotagminas
Límite:
Humans
Idioma:
En
Revista:
Cell Adh Migr
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos