Development of 5-silylethynyl-1,3-dioxolan-4-one as a new prochiral template for asymmetric phase-transfer catalysis.

ABSTRACT

Phase-transfer catalyzed asymmetric alkylation and Michael addition of 5-silylalkynyl-1,3-dioxolan-4-one were developed as a novel strategy to provide highly modular tertiary α-alkyl-α-hydroxy acids bearing an alkyne moiety.