[Anti-VEGF inhibitors and their role in the treatment of diabetic macular oedema]. / Die Rolle der Anti-VEGF-Therapie in der Behandlung des diabetischen Makulaödems.
Klin Monbl Augenheilkd
; 227(9): 701-11, 2010 Sep.
Article
en De
| MEDLINE
| ID: mdl-20845250
ABSTRACT
Diabetic macular edema (DME) and proliferative retinopathy are common causes for blindness in middle-aged patients. The gold standard for treatment has been laser coagulation. Limitations of this therapy are refractive DME, ischaemic diabetic maculopathy and complications after laser application. The need for a non-destructive and effective strategy has led to investigations regarding vascular endothelial growth factor (VEGF) inhibitors for reduction of vessel leakage and oedema formation. VEGF antibody fragments have been approved for age-associated macular degeneration (AMD) in different countries and have proved to be safe and effective. Trials for different anti-VEGF compounds are nearing completion or are completed. Published data show a superiority of anti-VEGF therapy compared to laser coagulation. In the present article, data regarding dose, injection scheme and practicable application form are reviewed.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Edema Macular
/
Inhibidores de la Angiogénesis
/
Factor A de Crecimiento Endotelial Vascular
/
Retinopatía Diabética
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Middle aged
Idioma:
De
Revista:
Klin Monbl Augenheilkd
Año:
2010
Tipo del documento:
Article