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ChemMatrix(®) for complex peptides and combinatorial chemistry.
García-Ramos, Yésica; Paradís-Bas, Marta; Tulla-Puche, Judit; Albericio, Fernando.
Afiliación
  • García-Ramos Y; Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, Barcelona, Spain.
J Pept Sci ; 16(12): 675-8, 2010 Dec.
Article en En | MEDLINE | ID: mdl-20853309
CM resin is a totally PEG-based resin, made exclusively from primary ether bonds and therefore highly chemically stable. Compared to other PEG resins, it exhibits good loading and is user friendly because of its free-flowing form upon drying. It shows improved performance over PS resins for the preparation of hydrophobic, highly structured poly-Arg peptides. In combination with ψPros, it allows the synthesis of small proteins such as the chemokine RANTES. Like other PEG-based resins, CM resin swells well in biocompatible solvents such as water, thereby allowing on-bead screening. Furthermore, the high loading of this resin permits the use of a tiny quarter of a bead as a microreactor for HPLC and MALDI-TOF analysis, thus further extending its applications in the field of combinatorial chemistry.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Polietilenglicoles / Resinas Sintéticas / Técnicas Químicas Combinatorias Idioma: En Revista: J Pept Sci Asunto de la revista: BIOQUIMICA Año: 2010 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos / Polietilenglicoles / Resinas Sintéticas / Técnicas Químicas Combinatorias Idioma: En Revista: J Pept Sci Asunto de la revista: BIOQUIMICA Año: 2010 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido