HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus.
Oral Dis
; 17(3): 309-13, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-20860769
ABSTRACT
OBJECTIVES:
Oral Lichen Planus (OLP) is associated with hepatitis C virus (HCV) infection and resembles graft-versus-host disease (GVHD) both clinically and histologically. The killer cell immunoglobulin-like receptor (KIR) genes encode a family of receptors expressed on NK and T cells and are supposed to play a significant role in GVHD and HCV infection. The aim of this study was to analyze the association among OLP, HCV infection and variants in KIR gene expression.METHODS:
A total of 81 patients with OLP (36 HCV+ve and 45 HCV-ve) and 217 healthy controls (HCV-ve) were typed for the presence of eight KIR genes and of HLA-Cw* alleles by polymerase chain reaction-sequence specific primer.RESULTS:
There were no significant differences in the frequency of the KIR genes and HLA-C1/C2 group alleles between cases and controls. We only found a significant difference in the frequency of the gene KIR2DL2 between HCV+ve and HCV-ve OLP patients.CONCLUSIONS:
The present data suggest that OLP is not associated with particular KIR genes or with HLA-Cw* alleles in patients without HCV infection. Contrarily, the role of the genes in OLP-HCV+ve patients remains unclear and might warrant further researches.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos HLA-C
/
Hepatitis C
/
Liquen Plano Oral
/
Receptores KIR
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Oral Dis
Asunto de la revista:
ODONTOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido