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Catechol O-methyltransferase pharmacogenomics and selective serotonin reuptake inhibitor response.
Ji, Y; Biernacka, J; Snyder, K; Drews, M; Pelleymounter, L L; Colby, C; Wang, L; Mrazek, D A; Weinshilboum, R M.
Afiliación
  • Ji Y; Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.
Pharmacogenomics J ; 12(1): 78-85, 2012 Feb.
Article en En | MEDLINE | ID: mdl-20877297
We applied a systematic pharmacogenetic approach to investigate the role of genetic variation in the gene encoding catechol O-methyltransferase (COMT) in individual variation in selective serotonin reuptake inhibitor (SSRI) response among depressed patients. In all, 23 single-nucleotide polymorphisms (SNPs) in COMT were genotyped using DNA from the Sequenced Treatment Alternatives to Relieve Depression (STAR(*)D) study (N=1914). One SNP, rs13306278, located in the distal promoter region of COMT, showed significant association with remission in White non-Hispanic (WNH) subjects (P=0.038). Electromobility shift assay for rs13306278 showed alternation in the ability of the variant sequence to bind nuclear proteins. A replication study was performed using samples from the Mayo Clinic Pharmacogenetics Research Network Citalopram/Escitalopram Pharmacogenomic study (N=422) that demonstrated a similar trend for association. Our findings suggest that novel genetic markers in the COMT distal promoter may influence SSRI response phenotypes.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacogenética / Catecol O-Metiltransferasa / Inhibidores Selectivos de la Recaptación de Serotonina / Polimorfismo de Nucleótido Simple / Trastorno Depresivo Mayor Límite: Humans Idioma: En Revista: Pharmacogenomics J Asunto de la revista: BIOLOGIA MOLECULAR / FARMACOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacogenética / Catecol O-Metiltransferasa / Inhibidores Selectivos de la Recaptación de Serotonina / Polimorfismo de Nucleótido Simple / Trastorno Depresivo Mayor Límite: Humans Idioma: En Revista: Pharmacogenomics J Asunto de la revista: BIOLOGIA MOLECULAR / FARMACOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos