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The impact of storage effects in biobanks on biomarker discovery in systems biology studies.
Balasubramanian, Raji; Mueller, Laurin; Kugler, Karl; Hackl, Werner; Pleyer, Lisa; Dehmer, Matthias; Graber, Armin.
Afiliación
  • Balasubramanian R; Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.
Biomarkers ; 15(8): 677-83, 2010 Dec.
Article en En | MEDLINE | ID: mdl-20923317
Sample handling and storage conditions in specimens frozen over long periods of time can severely impact marker levels. If laboratory technologies, practices and related protocols change over time, biomarker studies are potentially biased and report erroneous results. These issues and pitfalls are often overlooked in system biology studies using previously collected and stored materials, and are likely to be one notable cause for biomarker candidates failing to be validated. We present results from simulation studies quantifying the loss in statistical power to detect true biomarkers, due to diminishing concentration of analytes in samples subject to poor handling and storage conditions.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manejo de Especímenes / Biomarcadores / Biología de Sistemas Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Biomarkers Asunto de la revista: BIOQUIMICA Año: 2010 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Manejo de Especímenes / Biomarcadores / Biología de Sistemas Tipo de estudio: Guideline Límite: Humans Idioma: En Revista: Biomarkers Asunto de la revista: BIOQUIMICA Año: 2010 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido