Chromatography-free Wittig reactions using a bifunctional polymeric reagent.
Org Lett
; 12(21): 4996-9, 2010 Nov 05.
Article
en En
| MEDLINE
| ID: mdl-20936814
ABSTRACT
The first example of a polystyrene bearing two distinct reagent groups has been prepared. This phosphine and amine functionalized material was used in one-pot Wittig reactions with an aldehyde and either an α-halo-ester, -ketone, or -amide. Due to the heterogeneous nature of the polymer, the desired alkene product of these reactions could be isolated in excellent yield in essentially pure form after only filtration and solvent removal.
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2010
Tipo del documento:
Article