Using a portable ion mobility spectrometer to screen dietary supplements for sibutramine.
J Pharm Biomed Anal
; 54(3): 469-74, 2011 Feb 20.
Article
en En
| MEDLINE
| ID: mdl-20940091
ABSTRACT
In response to recent incidents of undeclared sibutramine, an appetite suppressant found in dietary supplements, we developed a method to detect sibutramine using hand-held ion mobility spectrometers with an analysis time of 15 s. Ion mobility spectrometry is a high-throughput and sensitive technique that has been used for illicit drug, explosive, volatile organic compound and chemical warfare detection. We evaluated a hand-held ion mobility spectrometer as a tool for the analysis of supplement extracts containing sibutramine. The overall instrumental limit of detection of five portable ion mobility spectrometers was 2 ng of sibutramine HCl. When sample extractions containing 30 ng/µl or greater of sibutramine were analyzed, saturation of the ionization chamber of the spectrometer occurred and the instrument required more than three cleaning cycles to remove the drug. Hence, supplement samples suspected of containing sibutramine should be prepared at concentrations of 2-20 ng/µl. To obtain this target concentration range for products containing unknown amounts of sibutramine, we provided a simple sample preparation procedure, allowing the U.S. Food and Drug Administration or other agencies to screen products using the portable ion mobility spectrometer.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Depresores del Apetito
/
Análisis Espectral
/
Suplementos Dietéticos
/
Ciclobutanos
/
Compuestos Orgánicos Volátiles
/
Iones
Límite:
Humans
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos