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Pneumococcal nasopharyngeal carriage following reduced doses of a 7-valent pneumococcal conjugate vaccine and a 23-valent pneumococcal polysaccharide vaccine booster.
Russell, F M; Carapetis, J R; Satzke, C; Tikoduadua, L; Waqatakirewa, L; Chandra, R; Seduadua, A; Oftadeh, S; Cheung, Y B; Gilbert, G L; Mulholland, E K.
Afiliación
  • Russell FM; Centre for International Child Health, Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Victoria, Australia. fmruss@unimelb.edu.au
Clin Vaccine Immunol ; 17(12): 1970-6, 2010 Dec.
Article en En | MEDLINE | ID: mdl-20943882
This study was conducted to evaluate the effect of a reduced-dose 7-valent pneumococcal conjugate vaccine (PCV) primary series followed by a 23-valent pneumococcal polysaccharide vaccine (23vPPS) booster on nasopharyngeal (NP) pneumococcal carriage. For this purpose, Fijian infants aged 6 weeks were randomized to receive 0, 1, 2, or 3 PCV doses. Within each group, half received 23vPPS at 12 months. NP swabs were taken at 6, 9, 12, and 17 months and were cultured for Streptococcus pneumoniae. Isolates were serotyped by multiplex PCR and a reverse line blot assay. There were no significant differences in PCV vaccine type (VT) carriage between the 3- and 2-dose groups at 12 months. NP VT carriage was significantly higher (P, <0.01) in the unvaccinated group than in the 3-dose group at the age of 9 months. There appeared to be a PCV dose effect in the cumulative proportion of infants carrying the VT, with less VT carriage occurring with more doses of PCV. Non-PCV serotype (NVT) carriage rates were similar for all PCV groups. When groups were pooled by receipt or nonreceipt of 23vPPS at 12 months, there were no differences in pneumococcal, VT, or NVT carriage rates between the 2 groups at the age of 17 months. In conclusion, there appeared to be a PCV dose effect on VT carriage, with less VT carriage occurring with more doses of PCV. By the age of 17 months, NVT carriage rates were similar for all groups. 23vPPS had no impact on carriage, despite the substantial boosts in antibody levels.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Streptococcus pneumoniae / Nasofaringe / Inmunización Secundaria / Vacunación / Vacunas Neumococicas Tipo de estudio: Clinical_trials Límite: Female / Humans / Infant / Male Idioma: En Revista: Clin Vaccine Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2010 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Streptococcus pneumoniae / Nasofaringe / Inmunización Secundaria / Vacunación / Vacunas Neumococicas Tipo de estudio: Clinical_trials Límite: Female / Humans / Infant / Male Idioma: En Revista: Clin Vaccine Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA / TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2010 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos