Meta-analysis of passive immunoprophylaxis in paediatric patients at risk of severe RSV infection.
Acta Paediatr
; 100(3): 324-9, 2011 Mar.
Article
en En
| MEDLINE
| ID: mdl-20950412
ABSTRACT
AIM:
To review respiratory syncytial virus (RSV), passive immunoprophylaxis (PI) trials and meta-analysis (MA).METHODS:
A literature review.RESULTS:
Two MA of PI were found. Overall 3927 patients were randomized. PI reduces RSV hospitalization in patients with bronchopulmonary dysplasia (RR 0.58; 95% CI 0.41, 0.82) and with acyanotic congenital heart disease (RR 0.29; 95% CI 0.14, 0.62). In patients with cyanotic heart disease or premature infants without bronchopulmonary dysplasia, results are inconclusive. Passive immunoprophylaxis has a null effect in mechanical ventilation and death.CONCLUSION:
Passive immunoprophylaxis reduces RSV hospitalization in a subset of patients. However, it has no effect in harder endpoints of RSV disease severity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunización Pasiva
/
Infecciones por Virus Sincitial Respiratorio
/
Anticuerpos Monoclonales
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Límite:
Humans
/
Infant
Idioma:
En
Revista:
Acta Paediatr
Año:
2011
Tipo del documento:
Article
País de afiliación:
España