[Skin abnormalities as first sign of Waldenström macroglobulinaemia]. / Huidafwijkingen als eerste teken van macroglobulinemie van Waldenström.

ABSTRACT

Small-vessel vasculitis was found in a 56-year-old female patient as the first sign of Waldenström macroglobulinemia. After the diagnosis was made by immunological investigation, she was treated successfully by combination therapy with rituximab, cyclophosphamide, vincristine en prednisone. Leukocytoclastic vasculitis occurs in only 5% of patients with Waldenström macroglobulinaemia as the first manifestation of this condition.